In this article, we continue our look at other cannabinoids found in hemp and cannabis.
In July, we published our first look at different naturally occurring cannabinoids that are less well known than THC and CBD. There, we discussed the benefits of CBG (Cannabigerol), CBC (Cannabichromene), THCV (Tetrahydrocannabivarin), and CBN (Cannabinol). The article sparked some good discussion on social media and we’re hoping for the same with this one as we follow up with four more cannabinoids of note.
This time, we’re going to discuss CBC-a (Cannabichromenic Acid), CBDV (Cannabidvarin), CBG-a (Cannabigerolic Acid), and CBCV (Cannabichromevarin). While these cannabinoids do show promise, they seem to be a lower priority for researchers. But hopefully, as researchers and scientists continue studying other cannabinoids, more information will become available on these lower tiered compounds.
CANNABICHROMENIC ACID (CBC-A)
The first cannabinoid we’re going to discuss is CBC-a (Cannabichromenic Acid).
CBC-a is the precursor to one of the most highly sought after cannabinoids, CBC (Cannabichromene). Like four other cannabinoids, CBC-A appears in the cannabis plant through decarbing. CBCA is non-psychoactive like CBD and has strong antimicrobial and analgesic (pain-relieving) properties. According to Maximum Yield, the most abundant levels of CBC-a are found in tropical strains of psychoactive cannabis (“marijuana”) with much lower levels found in other types of cannabis. According to current research, plants begin secreting cannabichromenic acid in the early seedling stage, before they create THC (Tetrahydrocannabinol). CBC-a can be converted to CBC through an aging and heating off the acid thru decarboxylation.
- Antimicrobial and analgesic properties
- Anti-viral and anti-inflammatory
Next up is CBDV (Cannabidvarin).
Like CBCA and most other cannabinoids we’ve discussed, CBDV is a non-psychoactive cannabinoid that has a similar makeup to CBD. Cannabis or hemp strains with higher levels of CBD tend to have higher levels of CBDV as well. Currently there hasn’t been much research on CBDV. Preliminary research shows that CBDV reduces nausea and seizures.
- Anti-nausea. A study in 2013 by the British Journal of Pharmacology researched the potential of CBDV and THCV’s anti-nausea’s effect on rats’ brains. Researchers concluded that both cannabinoids “may have potential in reducing nausea.” Just by the quote alone, it’s apparent more research needs to be done.
- Anti-seizures. Initial studies show that CBDV acts in a similar way to anti-convulsive medication Capsaicin, which targets the TRP channels (transient receptor potential channel) to combat the gradual process of brain development epilepsy. In fact, an Italian research team found that both CBDV and Capsaicin dephosphorylated TRPV1. CBDV’s effects on TRP channels are being studied to fully understand this cannabinoids anticonvulsive ability. One pharmaceutical company, GW Pharmaceuticals, is actively developing CBDV products for research in clinical trials. They are currently in a phase 2- trial CBDV product under the name GWP42006 that they’re hoping to be approved in treating adults with epilepsy.
CANNABIGEROLIC ACID (CBG-A)
The next in our list of other cannabinoids is CBG-a (Cannabigerolic Acid).
CBGA is considered the “cannabinoid stem cell.” Without CBGA, the amazing health benefits of THCa/THC, CBDa/CBD, CBCa/CBC, and CBG would not exist! These other cannabinoids form through biosynthesis, where chemicals combine to form new compounds. Studies show that industrial hemp contains high levels of CBGa, with some plants carrying up to 94% CBG!
- Analgesic. CBGa has been found to be an analgesic, meaning it provided pain relief.
- Anti-bacterial. CBGA delays the growth of new bacteria.
- Anti-inflammatory. CBGa reduces inflammation systematically.
- Biosynthesis. Without CBGa the medicinal benefits of the other cannabinoids wouldn’t exist. This is important. So much so that scientists aren’t directly studying this cannabinoid. Instead, funding and research are all going to better understand how the biosynthesis itself works.
The last other cannabinoid we’re going to talk about is CBCV (Cannabichromevarin).
CBCV was first discovered in 1975 when researchers at the University of Nagasaki in Thailand islolated the compound from the cannabis plant. This cannabinoid is the precursor to Cannabichromene (CBC). Cannabis strains with lower levels of THC and CBD often have higher levels of CBCV.
- Anti-convulsive. One of the major benefits of CBCV is its anticonvulsant properties. Researchers from the Regents of the University of California have a patent on an anticonvulsant drug for infants dealing with seizures. Although the primary compound in the drug is CBD, the University of California mentions both CBCV and CBC in the patent as well.
- Anandamide (AEA) reuptake inhibitor. Anandamide is a naturally occurring cannabinoid in humans. Researchers found that CBCV blocks Anandamide’s absorption by our brain and keeps it working for longer in our bodies.
- Very similar medical benefits to CBC, CBCV is a powerful anti-inflammatory, antidepressant, antibiotic, analgesic and antifungal and may be beneficial for patients suffering from:
- Chronic pain
- Major depression
- Epileptic seizures
- Crohn’s disease
- Alzheimer’s disease
WAR ON DRUGS INTERFERES WITH RESEARCH INTO OTHER CANNABINOIDS
In the span of two articles we shared 8 different cannabinoids, plus CBD and THC, which we discuss at great lengths in other articles. That’s 10 of the most researched and medically beneficial cannabinoids!
This time around we weren’t able to go as in-depth as we normally would in these types of articles because there just wasn’t enough information on these other cannabinoids just yet. We know scientists believe there are over 100 cannabinoids in the cannabis plant. Research and funding opportunities are still very limited. Cannabis and hemp are both classified as a Schedule I drug by the Drug Enforcement Administration. This classification means the agency refuses to acknowledge that these plants have any medical benefits, despite the evidence to the contrary.
Until this changes, the war on drugs limits our knowledge of the benefits of these miraculous plants. Fortunately, we believe that this will soon change for the better.
In the meantime, read and get to know the cannabinoids we shared, and learn about how they might help people like you.
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